Induced Pluripotent Stem Cells (iPSC)

The Application of Induced Pluripotent Stem Cells in Pathogenesis Study and Gene Therapy for Vascular Disorders.

Vascular disorders are complex diseases with high morbidity and mortality. Among them, the dilated macrovascular diseases (MVD), such as aortic aneurysm and aortic dissection, have presented a huge threat to human health. The pathogenesis of vascular diseases is mostly associated with property alteration of vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs). Studies have confirmed that induced pluripotent stem cells (iPSCs) can be proliferated and differentiated into other somatic cells, such as VECs and VSMCs. And patient-specific cells could provide detailed human-associated information in regard to pathogenesis or drug responses. In addition, differentiated ECs from iPSC have been widely used in disease modeling as a cell therapy.

Gene Therapy in iPSC Models for Vascular Diseases


Because of the lack of stable donor sources, tissue or organ replacement therapy cannot be carried out sufficiently. Therefore, iPSC is a new and better approach to generate tissue and organ. The target organs derived from autologous iPSCs will greatly dismiss immune response during transplantation. The iPSCs corrected by the gene editing technology will repair the pathological lesions and completely cure the disease.